FDA
Breakthrough Device Designation
GrantedMarch 2026
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Noninvasive hemodynamic insight for heart failure care

Coredio estimates catheter-grade intracardiac hemodynamics from wearables, using AI and physics-based digital twins.

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Coredio clinician dashboard, patient app, and reading timer

What Coredio is

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Coredio CPSE, the Cardiac Performance Simulation Engine, builds a personalized digital twin of each patient’s cardiovascular system,

turning everyday wearable data into the intracardiac measures clinicians rely on for guideline-directed medical therapy. No implant. No procedure.

Physics-based digital twin
Trained on clinical data
Watch and cuff inputs
LVEDP, CVP, CI, SVR

The challenge

Cardiac monitoring today is fragmented, costly, and invasive

Clinician overwhelmed at a monitoring station

Insufficient monitoring

Patients waiting in a clinic waiting room

Limited access between visits

Clinician with a patient in a hospital bed

Invasive and costly

The platform solution

Noninvasive, personalized heart monitoring through AI, digital twins, and everyday wearables.

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Clinician measuring a patient's blood pressure

Patient eligibility

Patient eligibility

The solution

Catheter-grade hemodynamics, anywhere the patient is

Left Ventricular End-Diastolic Pressure (LVEDP) rises before symptoms appear, flagging worsening heart failure early.

Cross-section of a human heart with the left ventricle marked

Cardiac Index (CI) scales cardiac output to body size, showing whether blood flow is meeting metabolic demand.

Cross-section of a human heart with cardiac output marked

Central Venous Pressure (CVP) signals volume overload or right heart strain, an early indicator of decompensation.

Cross-section of a human heart with the central venous return marked

Elevated Systemic Vascular Resistance (SVR) increases cardiac workload and reduces output, a marker of worsening heart failure.

Diagram of the systemic and pulmonary circulation

Our ecosystem

A connected ecosystem designed for clinical rigor and patient simplicity.

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Coredio

Monitoring workflow

A simple workflow that fits existing care, without added complexity

Patient personalization

During routine initial checkups, Coredio automatically builds a personalized patient model in the background.

Home setup

Patients are set up with a smartwatch and BP cuff for home use. Coredio provides a watch if they don't have one.

Remote monitoring

Coredio estimates hemodynamic status from daily smartwatch and blood pressure readings.

Clinical review & reporting

Care teams review patient-specific alerts and intervene early.

Precision

Coredio’s technology features

Validated Against Catheterization

Spot-Check Hemodynamic Status

Catheter-Grade Estimates

Testimonial

Built for the entire care continuum

Dr. Jagmeet P. Singh, MGH

“Coredio’s wearable-derived signals and physics-informed AI could help close the gap between hospital-based measurements and at-home heart failure monitoring, giving clinicians earlier visibility into patient physiology. FDA Breakthrough Device Designation reflects the clinical need this technology addresses.”

Dr. Jagmeet P. Singh, MGH

Mass General Brigham

Frequently asked questions

No. Coredio is entirely noninvasive. It relies on wearable sensors such as a smartwatch and a blood pressure cuff. There are no implants, catheters, or surgical procedures involved.

Every heart is different. Coredio builds a model from your own baseline measurements, then tracks your individual cardiovascular trends over time and shares them with your clinician. The aim is earlier, smarter intervention before a small change becomes a serious one.

A compatible smartwatch and a blood pressure cuff. If you don't already have a watch, we'll provide one as part of your home setup.

Coredio is designed for clinicians managing heart failure patients and for the patients themselves who benefit from at-home hemodynamic monitoring.

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with the Coredio team

Join the clinicians who are exploring the future of cardiovascular monitoring

Device cluster